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Why are older women predisposed to osteoarthritis?

Why are older women predisposed to osteoarthritis?

One recent study in mice uncovered that menopause led to a drop in 17beta-estradiol and progesterone, which increased cartilage aging, degeneration, and disassembly of the extracellular matrix.

By Accordss Hospital

20 Mar 2025

1 min read

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Osteoarthritis is a condition that can affect joint mobility and cause joint pain. Experts are interested in understanding the relationship between experiencing menopause and the risk for osteoarthritis.


A study recently published in Nature AgingTrusted Source

 used mouse models and human cells to explore this relationship.


Researchers found that loss of 17beta-estradiol and progesterone in mice with chemically induced menopause affected cartilage degeneration.


Similarly, treatment with 17beta-estradiol and progesterone protected against cartilage degeneration in mice and appeared to improve human cartilage cells, too.

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